Newborn screening for SCID: lessons learned. Issue 6 (2nd June 2016)

• Record Type: Journal Article
• Authors: Buelow, Becky J.; Verbsky, James W.; Routes, John M.
• Is Part Of: Expert review of hematology. Volume 9:Issue 6(2016)
• Page Start: 579
• Page End: 584
• Publication Date: 2016-06-02
• Subjects: Newborn screening (NBS) -- severe combined immunodeficiency (SCID) -- T cell lymphopenia (TCL) -- T cell receptor excision circle (TREC) -- review; Hematology -- Periodicals; 616.15005
• DOI: 10.1080/17474086.2016.1180243
• Languages: English
• ISSNs: 1747-4086

Abstract

ABSTRACT: Introduction : Newborn screening (NBS) for Severe combined immunodeficiency (SCID)/severe T cell lymphopenia (sTCL) is being increasingly used worldwide. Areas covered : In this manuscript we will discuss the following: 1) The rationale for screening newborns for SCID/sTCL; 2) The scientific basis for the use of the T cell receptor excision circle (TREC) assay in screening newborns for SCID/sTCL; 3) The published outcomes of current NBS programs. Expert commentary : 4) Some of the ethical dilemmas that occur when screening newborns for SCID. Finally, we will discuss the future directions for expanding NBS to include other primary immunodeficiencies.