Jurassic PARK2: You eat your mitochondria, and you are what your mitochondria eat. Issue 3 (3rd March 2016)

• Record Type: Journal Article
• Authors: Dorn, Gerald W.
• Is Part Of: Autophagy. Volume 12:Issue 3(2016)
• Page Start: 610
• Page End: 611
• Publication Date: 2016-03-03
• Subjects: Heart -- metabolomics -- mitofusin 2 -- mitophagy -- Parkin -- transcriptomics; Autophagic vacuoles -- Periodicals; Apoptosis -- Periodicals; Cell death -- Periodicals; Lysosomes -- Periodicals; Degeneration (Pathology) -- Periodicals; Autophagy -- Periodicals; Cell Death -- Periodicals; Lysosomes -- Periodicals; Periodicals; 571.936
• DOI: 10.1080/15548627.2016.1143210
• Languages: English
• ISSNs: 1554-8627

Abstract

ABSTRACT: Park2/Parkin is a central mediator of selective mitochondrial autophagy for mitochondrial quality control. We showed in mouse hearts that PINK1/Mfn2/Park2 mediated generalized mitophagy is essential to the normal perinatal transition from fetal mitochondria that prefer carbohydrates as metabolic substrates to adult fatty-acid metabolizing mitochondria. Our findings demonstrate how functional interactions between mitophagic mitochondrial removal and biogenic mitochondrial replacement facilitate metabolic maturation of the heart.