STK38 at the crossroad between autophagy and apoptosis. Issue 3 (3rd March 2016)

• Record Type: Journal Article
• Authors: Joffre, Carine; Codogno, Patrice; Fanto, Manolis; Hergovich, Alexander; Camonis, Jacques
• Is Part Of: Autophagy. Volume 12:Issue 3(2016)
• Page Start: 594
• Page End: 595
• Publication Date: 2016-03-03
• Subjects: apoptosis -- autophagy -- Beclin1 -- Hippo pathway -- NDR protein kinase; Autophagic vacuoles -- Periodicals; Apoptosis -- Periodicals; Cell death -- Periodicals; Lysosomes -- Periodicals; Degeneration (Pathology) -- Periodicals; Autophagy -- Periodicals; Cell Death -- Periodicals; Lysosomes -- Periodicals; Periodicals; 571.936
• DOI: 10.1080/15548627.2015.1135283
• Languages: English
• ISSNs: 1554-8627

Abstract

Abstract: We describe the STK38 protein kinase as a conserved regulator of autophagy. We discovered STK38 as a novel binding partner of Beclin1, a key regulator of autophagy. By combining molecular, cell biological and genetic approaches, we show that STK38 promotes autophagosome formation in human cells and in Drosophila . Furthermore, we also provide evidence demonstrating that STK38 with the small GTPase RalB, assist the co-ordination between autophagic and apoptotic events upon autophagy induction, hence proposing a role for STK38 in determining cellular fate in response to autophagic conditions.