4E-BP1, a multifactor regulated multifunctional protein. Issue 6 (18th March 2016)

• Record Type: Journal Article
• Authors: Qin, Xiaoyu; Jiang, Bin; Zhang, Yanjie
• Is Part Of: Cell cycle. Volume 15:Issue 6(2016)
• Page Start: 781
• Page End: 786
• Publication Date: 2016-03-18
• Subjects: cancer -- eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 -- kinase -- mTOR -- overexpression -- phosphorylation; Cell cycle -- Periodicals; 571.84377
• DOI: 10.1080/15384101.2016.1151581
• Languages: English
• ISSNs: 1538-4101

Abstract

ABSTRACT: Eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1) is a member of a family of translation repressor proteins, and a well-known substrate of mechanistic target of rapamycin (mTOR) signaling pathway. Phosphorylation of 4E-BP1 causes its release from eIF4E to allow cap-dependent translation to proceed. Recently, 4E-BP1 was shown to be phosphorylated by other kinases besides mTOR, and overexpression of 4E-BP1 was found in different human carcinomas. In this review, we summarize the novel findings on mTOR independent 4E-BP1 phosphorylation in carcinomas. The implications of overexpression and possible multi-function of 4E-BP1 are also discussed.