2′-Modified Guanosine Analogs for the Treatment of HCV. (2nd June 2016)

• Record Type: Journal Article
• Authors: Girijavallabhan, Vinay; Arasappan, Ashok; Bennett, Frank; Chen, Kevin; Dang, Qun; Huang, Ying; Kerekes, Angela; Nair, Latha; Pissarnitski, Dmitri; Verma, Vishal; Alvarez, Carmen; Chen, Ping; Cole, David; Esposite, Sara; Huang, Yuhua; Hong, Qingmei; Liu, Zhidan; Pan, Weidong; Pu, Haiyan; Rossman, Randall; Truong, Quang; Vibulbhan, Bancha; Wang, Jun; Zhao, Zhiqiang; Olsen, David; Stamford, Andrew; Bogen, Stephane; Njoroge, F. George
• Is Part Of: Nucleosides, nucleotides & nucleic acids. Volume 35:Number 6(2016)
• Page Start: 277
• Page End: 294
• Publication Date: 2016-06-02
• Subjects: Nucleosides -- Periodicals; Nucleotides -- Periodicals; Nucleic acids -- Periodicals; 572.8
• DOI: 10.1080/15257770.2016.1154968
• Languages: English
• ISSNs: 1525-7770

Abstract

ABSTRACT: Novel 2′-modified guanosine nucleosides were synthesized from inexpensive starting materials in 7–10 steps via hydroazidation or hydrocyanation reactions of the corresponding 2′-olefin. The antiviral effectiveness of the guanosine nucleosides was evaluated by converting them to the corresponding 5′-O-triphosphates (compounds38–44 ) and testing their biochemical inhibitory activity against the wild-type NS5B polymerase.