Use of a Ureido-Substituted Deoxycytidine Module for DNA Assemblies. (2nd July 2016)

• Record Type: Journal Article
• Authors: Nakano, Shu-ichi; Oka, Hirohito; Fujii, Masayuki; Sugimoto, Naoki
• Is Part Of: Nucleosides, nucleotides & nucleic acids. Volume 35:Number 7(2016)
• Page Start: 370
• Page End: 378
• Publication Date: 2016-07-02
• Subjects: Deoxycytidine derivative -- stacking -- thermal stability -- i-motif DNA; Nucleosides -- Periodicals; Nucleotides -- Periodicals; Nucleic acids -- Periodicals; 572.8
• DOI: 10.1080/15257770.2016.1174262
• Languages: English
• ISSNs: 1525-7770

Abstract

ABSTRACT: Ureido-substituted cytosine derivatives are promising for constructing self-assembly structures that can be applied to nanotechnology research. However, conventional cytosine modules achieve assembly in organic solvents. In this study, an N-phenylcarbamoyl deoxycytidine nucleoside was incorporated into a C-rich oligonucleotide to achieve self-assembly in aqueous solution. The results show that the capability of the module to form DNA assemblies varied depending on the number of modules incorporated. The deoxycytidine derivative has a potential application in the development of smart materials based on DNA assembly.