A new cytotoxic biflavonoid from the rhizome of Wikstroemia indica. Issue 12 (17th June 2016)

• Record Type: Journal Article
• Authors: Shao, Meng; Huang, Xiao-Jun; Liu, Jun-Shan; Han, Wei-Li; Cai, Hong-Bing; Tang, Qing-Fa; Fan, Qin
• Is Part Of: Natural product research. Volume 30:Issue 12(2016)
• Page Start: 1417
• Page End: 1422
• Publication Date: 2016-06-17
• Subjects: Wikstroemia indica -- biflavonoid -- 3′-hydroxydaphnodorin A -- cytotoxicity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2015.1062379
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract : One new chalcone-flavone biflavonoid, 3′-hydroxydaphnodorin A (1 ), together with 12 known biflavonoids (2 –13 ), was isolated from the rhizome of Wikstroemia indica . Their structures were established on the basis of extensive spectroscopic methods. Eight isolated compounds1 –3, 6, 7, 9, 12 and13 were evaluated for their cytotoxic activities against cancer-derived cell lines Hep3B, HepG2 and CNE2, and1 was found to possess moderate cytotoxicity against HepG2 and CNE2 cell lines, with IC50 values of 65.5 ± 11.4 and 53.6 ± 10.1 μM, respectively. Abstract :