A bioactive cycloartane triterpene from Garcinia hombroniana. Issue 12 (17th June 2016)

• Record Type: Journal Article
• Authors: Jamila, Nargis; Khan, Naeem; Khan, Imran; Khan, Amir Atlas; Khan, Sadiq Noor
• Is Part Of: Natural product research. Volume 30:Issue 12(2016)
• Page Start: 1388
• Page End: 1397
• Publication Date: 2016-06-17
• Subjects: Garcinia hombroniana -- (22Z, 24E)-3β-hydroxycycloart-14, 22, 24-trien-26-oic acid -- acetylcholinesterase -- butyrylcholinesterase; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2015.1060594
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: The dichloromethane bark extract of Garcinia hombroniana yielded one new cycloartane triterpene; (22 Z, 24 E )-3 β -hydroxycycloart-14, 22, 24-trien-26-oic acid (1 ) together with five known compounds: garcihombronane G (2 ), garcihombronane J (3 ), 3 β acetoxy-9 α -hydroxy-17, 14-friedolanostan-14, 24-dien-26-oic acid (4 ), (22 Z, 24 E )-3 β, 9 α -dihydroxy-17, 14-friedolanostan-14, 22, 24-trien-26-oic acid (5 ) and 3 β, 23 α -dihydroxy-17, 14-friedolanostan-8, 14, 24-trien-26-oic acid (6 ). Their structures were established by the spectral techniques of NMR and ESI-MS. These compounds together with some previously isolated compounds; garcihombronane B (7 ), garcihombronane D (8 ) 2, 3', 4, 5'-tetrahydroxy-6-methoxybenzophenone (9 ), volkensiflavone (10 ), 4''- O -methyll-volkensiflavone (11 ), volkensiflavone-7- O -glucopyranoside (12 ), volkensiflavone-7- O -rhamnopyranoside (13 ), Morelloflavone (14 ), 3''- O -methyl-morelloflavone (15 ) and morelloflavone-7- O -glucopyranoside (16 ) were evaluated for cholinesterase enzymes inhibitory activities using acetylcholinesterase and butyrylcholinesterase. In these activities, compounds1–9 showed good dual inhibition on both the enzymes while compounds10–16 did not reasonably contribute to both the cholinesterases inhibitory effects. Graphical abstract: