Inhibitors of LSD1 as a potential therapy for acute myeloid leukemia. (2nd July 2016)

• Record Type: Journal Article
• Authors: Przespolewski, Amanda; Wang, Eunice S.
• Is Part Of: Expert opinion on investigational drugs. Volume 25:Number 7(2016:Jul.)
• Page Start: 771
• Page End: 780
• Publication Date: 2016-07-02
• Subjects: Acute myeloid leukemia -- epigenetics -- lysine specific demethylase -- LSD1 -- tranylcypromine analogues; Drugs -- Design -- Periodicals; Drugs, Investigational -- Bibliography; Drugs, Investigational -- Periodicals; 615.1
• DOI: 10.1080/13543784.2016.1175432
• Languages: English
• ISSNs: 1354-3784

Abstract

ABSTRACT: Introduction : Epigenetic dysregulation plays a critical role in the pathogenesis of acute myeloid leukemia (AML). Alterations in histone methylation lead to aberrant silencing of expression of multiple genes involved in tumor suppression and cell cycling, resulting in myeloid maturation arrest and proliferation of early myeloid progenitors. One promising approach targeting chromatin regulatory proteins is inhibition of lysine specific demethylase-1 (LSD1), an enzyme responsible for demethylation of histone H3 as well as other functions Areas covered : Available literature on LSD1 in normal and malignant hematopoiesis was identified in PubMed and reviewed. Areas addressed here include the biology of LSD1, pharmacologic inhibitors, and preclinical data supporting the rationale for LSD1 inhibition in AML therapy. Expert opinion : LSD1 inhibitors represent a promising novel epigenetic approach for AML therapy. Preclinical studies have revealed that pharmacologic LD1 inhibitors function primarily by altering stem cell programs and restoring myeloid differentiation to AML cells. These effects are markedly enhanced in combination with trans-retinoic acid or histone deacetylase inhibitors with little toxicity. Currently, multiple oral LSD1 inhibitors are undergoing phase 1 investigation in patients with AML. The results of these clinical trials are eagerly awaited.