Synthesis of poly(ether esters) from reaction of alpha-cyano-4-hydroxycinnamic acid and group IVB metallocenes. Issue 6 (2nd June 2016)

• Record Type: Journal Article
• Authors: Carraher, Charles E.; Roner, Michael R.; Ayoub, Marian; Crichton, Ryan; Moric-Johnson, Alisa; Miller, Lindsey; Black, Kendra
• Is Part Of: Journal of macromolecular science. Volume 53:Issue 6(2016)
• Page Start: 328
• Page End: 334
• Publication Date: 2016-06-02
• Subjects: Group IVB-containing polymers -- metallocene-containing polymers -- hafnocene polymer -- zirconocene polymer -- titanocene polymers -- pancreatic cancer -- inhibition of cancer cell lines -- interfacial polymerization; Polymers -- Periodicals; Polymerization -- Periodicals; 547.7
• DOI: 10.1080/10601325.2016.1165993
• Languages: English
• ISSNs: 1060-1325

Abstract

ABSTRACT: Poly(ether esters) are rapidly synthesized in moderate yield employing the interfacial polycondensation reaction system from the reaction of alpha-cyano-4-hydroxycinnamic acid and Group IVB metallocenes. The products are high polymers. Infrared spectroscopy shows the formation of new bands derived from the M-O and M-O(CO) linkages. It also shows that the products exist as alternating M-O and M-O(CO) linkages. The products show outstanding inhibition of a variety of cancer cell lines including two pancreatic cancer cell lines. EC50 values for the polymers are in the nanogram/mL range. The ability to inhibit the cancer cell lines is generally Hf>Zr>Ti. Thus, future synthesis and testing might consider using compounds containing hafnocene and zirconocene in addition to the titanocene moiety.