Synthesis, structural characterization and preliminary cancer cell line results for polymers derived from reaction of titanocene dichloride and various poly(ethylene glycols). Issue 7 (2nd July 2016)

• Record Type: Journal Article
• Authors: Carraher, Charles E.; Roner, Michael R.; Reckleben, Lisa; Black, Kendra; Frank, Jessica; Crichton, Ryan; Russell, Floyd; Moric-Johnson, Alisa; Miller, Lindsey
• Is Part Of: Journal of macromolecular science. Volume 53:Issue 7(2016)
• Page Start: 394
• Page End: 402
• Publication Date: 2016-07-02
• Subjects: Metal containing polymers -- PEG polymers -- titanocene-containing polymers -- cancer -- pancreatic cancer -- water soluble polymers -- MALDI MS; Polymers -- Periodicals; Polymerization -- Periodicals; 547.7
• DOI: 10.1080/10601325.2016.1176440
• Languages: English
• ISSNs: 1060-1325

Abstract

ABSTRACT: We describe the initial synthesis of DMSO and water-soluble titanocene polyethers through reaction of the titanocene dichloride and various poly(ethylene glycols) employing commercially available reactants. Infrared, proton NMR, and MALDI MS results are consistent with the titanocene-containing polyether structure. The materials are polymeric with chain lengths ranging from 1500 to 4. They exhibit good inhibition of a variety of cancer cell lines including two pancreatic cancer cell lines.