Analytics of Quinine and its Derivatives. (3rd March 2016)

• Record Type: Journal Article
• Authors: Kluska, Mariusz; Marciniuk-Kluska, Anna; Prukała, Dorota; Prukała, Wiesław
• Is Part Of: Critical reviews in analytical chemistry. Volume 46:Number 2(2016)
• Page Start: 139
• Page End: 145
• Publication Date: 2016-03-03
• Subjects: Cinquinidine -- HPLC -- isotachophoresis -- malaria -- quinidine -- quinine; Chemistry, Analytic -- Periodicals; 543
• DOI: 10.1080/10408347.2014.996700
• Languages: English
• ISSNs: 1040-8347

Abstract

ABSTRACT: The objective of this study was to perform a synthesis and analysis of the most important information on quinine and its derivatives, which are still very important in the treatment of malaria. The analysis of stereoisomers of quinine and its derivatives was conducted using two techniques, high-performance liquid chromatography and capillary electrophoresis. Particularly noteworthy is the technique used for the determination of isotachophoresis, referred to as one of the so-called green chemistry techniques. Particular attention was paid to properties and the use of quinine and its derivatives in the treatment of malaria. The analytical part will supplement knowledge about quinidine, quinine, and cinchonidine, and will contribute to the growth of research on the so-much-needed drugs against malaria.