One-pot Synthesis of 5-Unsubstituted 3, 4-Dihydropyrimidin-2(1H)-ones from Aldehydes, Ketones, and Urea under Solvent-free Conditions. (26th May 2016)

• Record Type: Journal Article
• Authors: Song, Zhiguo; Sun, Xiaohu; Yang, Xibao
• Is Part Of: Polycyclic aromatic compounds. Volume 36:Number 3(2016)
• Page Start: 242
• Page End: 251
• Publication Date: 2016-05-26
• Subjects: 3, 4-dihydropyrimidin-2(1H)-ones -- heterocycles -- multi-component reactions -- solvent-free condition -- stannous chioride; Polycyclic aromatic compounds -- Periodicals; 547
• DOI: 10.1080/10406638.2014.967785
• Languages: English
• ISSNs: 1040-6638

Abstract

Abstract : Various 5-unsubstituted 3, 4-dihydropyrimidin-2(1 H )-ones were synthesized efficiently by a one-pot three-component condensation of aromatic aldehydes, aromatic ketones, and urea using SnCl2 ·2H2 O as a catalyst under solvent-free conditions. All products were identified by IR, NMR, MS, and elemental analysis. The novel method offers several advantages such as excellent yields (81–95%), short reaction time (5–16 min), broader substrate scope, and environmentally friendly conditions.