A numerical solution of the mechanical bidomain model. Issue 10 (26th July 2016)

• Record Type: Journal Article
• Authors: Gandhi, Samip; Roth, Bradley J.
• Is Part Of: Computer methods in biomechanics and biomedical engineering. Volume 19:Issue 10(2016)
• Page Start: 1099
• Page End: 1106
• Publication Date: 2016-07-26
• Subjects: Mechanical bidomain model -- finite difference -- cardiac tissue -- ischemia -- border zone -- mechanotransduction; Biomechanics -- Data processing -- Periodicals; Biomedical engineering -- Periodicals; Biomechanics -- Periodicals; Biomedical Engineering -- methods -- Periodicals; Computing Methodologies -- Periodicals; 612.7
• DOI: 10.1080/10255842.2015.1105964
• Languages: English
• ISSNs: 1025-5842

Abstract

Abstract: Introduction : The mechanical bidomain model predicts forces on integrin proteins in the membrane. It has been solved analytically for idealized examples, but a numerical algorithm is needed to address realistic problems. Methods : The bidomain equations are approximated using finite differences. An ischemic region is modeled as a circular area having no active tension, surrounded by normal tissue. Results : The membrane force is large in the ischemic border zone, but is small elsewhere. Strain is distributed widely throughout the ischemic region and surrounding tissue. Conclusion : This calculation provides a testable prediction for the mechanism of mechanotransduction and remodeling in cardiac tissue.