Hepatoprotective diterpenoids from the roots of Salvia grandifolia. Issue 5 (3rd May 2016)

• Record Type: Journal Article
• Authors: Kang, Jie; Zhang, Ting; Li, Li; Sun, Hua; Wang, Ding-Ding; Chen, Ruo-Yun
• Is Part Of: Journal of Asian natural products research. Volume 18:Issue 5(2016)
• Page Start: 504
• Page End: 508
• Publication Date: 2016-05-03
• Subjects: Lamiaceae -- Salvia grandifolia -- diterpenoid -- grandifolia G -- hepatoprotective activity; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2015.1130705
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: One new diterpenoid, grandifolia G (1 ), together with a known diterpenoid (6, 7, 8, 8a-tetrahydro-6, 6-dimethyl-2-oxonaphtho[1, 8-bc]furan-3-yl)-4-methylfuran-3-carboxylic acid (2 ), was isolated from 70% EtOH extract of root of Salvia grandifolia . Their structures were determined by UV, IR, HRESIMS, NMR spectra. Compounds1 and2 (10 μM) exhibited hepatoprotective activities (61 and 55%) against DL-galactosamine-induced cell damage in HL-7702 cells.