Fabrication of polyhydroxybutyrate (PHB)/γ-Fe2O3 nanocomposite film and its properties study. Issue 9 (12th June 2016)

• Record Type: Journal Article
• Authors: Moghaddam, Shokooh; Taghi Khorasani, Mohammad; Hosseinkazemi, Hesam; Biazar, Esmaeil; Fazeli, Mahyar
• Is Part Of: Journal of biomaterials science. Volume 27:Issue 9(2016)
• Page Start: 793
• Page End: 804
• Publication Date: 2016-06-12
• Subjects: Magnetic nanocomposite -- polyhydroxybuthyrate (PHB) -- γ-Fe2O3 nanoparticles -- physical and mechanical analyses -- cell separation; Polymers -- Biocompatibility -- Periodicals; Biomedical materials -- Periodicals; 572.33
• DOI: 10.1080/09205063.2016.1143320
• Languages: English
• ISSNs: 0920-5063

Abstract

Abstract: Magnetic separation has numerous advantages in isolating cancerous and normal cells used in the diagnosis and treatment sectors. Here, we produced magnetic nanocomposite films made of polyhydroxybutyrate (PHB)/magnetite nanoparticles (γ-Fe2 O3 ), and the properties of the films by SEM, TEM, FTIR, DMTA, contact angle, and cellular analyses were investigated. The microscopic images showed uniform distribution of γ-Fe2 O3 magnetic nanoparticles in polymeric matrix. The chemical bounds between magnetic nanoparticles and polymeric matrix demonstrated using the FTIR spectrophotometer. The DMTA and contact angle results indicated an increase in the glass transition temperature and hydrophilic properties of nanocomposites is achieved by increasing the magnetic nanoparticles amount in polymer matrix. The cellular results were showed that adhesion of cancer cells compared to normal cells was significantly enhanced by the induction of a magnetic field. These nanocomposite films can be used as a substrate for cellular adhesion and separation processes.