Fabrication and characterization of Mg-doped chitosan–gelatin nanocompound coatings for titanium surface functionalization. Issue 10 (2nd July 2016)

• Record Type: Journal Article
• Authors: Cai, Xinjie; Cai, Jing; Ma, Kena; Huang, Pin; Gong, Lingling; Huang, Dan; Jiang, Tao; Wang, Yining
• Is Part Of: Journal of biomaterials science. Volume 27:Issue 10(2016)
• Page Start: 954
• Page End: 971
• Publication Date: 2016-07-02
• Subjects: Magnesium -- chitosan -- gelatin -- coating -- electrophoretic deposition -- functionalization; Polymers -- Biocompatibility -- Periodicals; Biomedical materials -- Periodicals; 572.33
• DOI: 10.1080/09205063.2016.1170416
• Languages: English
• ISSNs: 0920-5063

Abstract

Abstract: Titanium and its alloys have been widely used in clinic and achieved great success. Due to the bio-inertness of titanium surface, challenges still exit in some compromised conditions. The present study aimed to functionalize titanium surface with magnesium (Mg)-doped chitosan/gelatin (CS/G) nanocompound coatings via electrophoretic deposition (EPD). CS/G coatings loaded with different amount of magnesium were successfully prepared on titanium substrate via EPD. Physicochemical characterization of the coatings confirmed that magnesium ions were loaded into the coatings in a dose-dependent manner. XRD results demonstrated that co-deposition of magnesium influenced the crystallinity of the coatings, and a new crystalline substance presented, namely hydrated basic magnesium carbonate. Mechanical tests showed improved tensile and shear bond strength of the magnesium-doped coatings, while the excessively high magnesium concentration could eventually decrease the bonding strength. Sustained release of magnesium ion was detected by ICP-OES within 28 days. TEM images also displayed that nanoparticles could be released from the coatings. In vitro cellular response assays demonstrated that the Mg-doped nanocompound coatings could enhance the proliferation and osteogenic differentiation of MC3T3-E1 cells compared to CS/G coatings. Therefore, it could be concluded that Mg-doped CS/G nanocompound coatings were successfully fabricated on titanium substrates via EPD. It would be a promising candidate to functionalize titanium surface with such organic–inorganic nanocompound coatings.