Breast Cancer Subtypes in Patients Aged 70 Years and Older. (27th May 2016)

• Record Type: Journal Article
• Authors: Königsberg, Robert; Pfeiler, Georg; Hammerschmid, Nicole; Holub, Oliver; Glössmann, Kerstin; Larcher-Senn, Julian; Dittrich, Christian
• Is Part Of: Cancer investigation. Volume 34:Number 5(2016)
• Page Start: 197
• Page End: 204
• Publication Date: 2016-05-27
• Subjects: Elderly patients -- Age categories -- DDFS -- LRFS -- adjuvant therapies -- breast cancer subtypes; Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.1080/07357907.2016.1182184
• Languages: English
• ISSNs: 0735-7907

Abstract

ABSTRACT: Recurrence and survival pattern in breast cancer (bc) patients (pts) ≥ 70 years subcategorized according to subtype and age are still an area of uncertainty. Tumor characteristics, patient demographics, therapies applied, and recurrence pattern were compared between luminal A (LA), luminal B (LB), Her2/neu overexpressing (Her+) and triple-negative (TN) bc subtypes and the age subcategories 70–74, 75–79, ≥80 years. Based on univariate Cox-regression-analyses distant-disease-free-survival (DDFS) differed significantly for bc subtypes ( p = 0.0002), notably for Her+ vs. LA ( p = 0.0014), TN vs. LA ( p < 0.001), and TN vs. LB ( p = 0.0086). Not age, but Her+ and TN represented prognostic factors for DDFS.