Study of the Determinants of Vitamin D Status in Pediatric Patients With Osteogenesis Imperfecta. (18th May 2016)

• Record Type: Journal Article
• Authors: Zambrano, Marina B.; Brizola, Evelise; Pinheiro, Bruna; Vanz, Ana Paula; Mello, Elza D.; Félix, Têmis Maria
• Is Part Of: Journal of the American College of Nutrition. Volume 35:Number 4(2016)
• Page Start: 339
• Page End: 345
• Publication Date: 2016-05-18
• Subjects: vitamin D -- osteogenesis imperfecta -- nutrition -- bone health -- health professional -- family education; Nutrition -- Periodicals; Nutrition disorders -- Periodicals; 613.2
• DOI: 10.1080/07315724.2015.1057776
• Languages: English
• ISSNs: 0731-5724

Abstract

Abstract : Objective: Vitamin D is essential to the development and maintenance of the skeleton, especially for children with bone disorders such as osteogenesis imperfecta (OI). We evaluated serum 25-hydroxyvitamin D (25-OHD) levels to assess the relationship between determinants of vitamin D status in pediatric patients with OI. Methods: This cross-sectional study evaluated sex, age, weight, height, body mass index, OI type, sunscreen use, season of assessment, sun exposure, vitamin D and calcium supplementation, bisphosphonate treatment, bone mineral density (BMD), milk and soda consumption, mobility, and time of sedentary activity. Levels of serum 25-OHD, calcium, parathyroid hormone (PTH), phosphorus, and alkaline phosphatase (ALP) were analyzed. Serum levels of 25-OHD were classified according to sufficient (>30 ng/ml or 75 nmol/L), insufficient (20–30 ng/ml or 50–75 nmol/L), moderately deficient (20–10 ng/ml or 50–25 nmol/L), and severely deficient (<10 ng/ml or 25 nmol/L). Results: Fifty-two patients were included and 46 (88.4%) were classified as having insufficient or deficient 25-OHD. An inverse correlation between serum 25-OHD and time of sedentary activity ( r = −0.597, p < 0.001) and a positive correlation with height ( r = 0.521, p = 0.046) and whole body BMD ( r = 0.586, p = 0.022) were observed. A significant difference between the number of glasses of milk consumed ( p = 0.010) was observed. Conclusion: To optimize bone health, patients with OI need to be educated regarding habits that can improve serum 25-OHD levels, such as a reduction in periods of inactivity, the importance of sun exposure, and increasing consumption of milk and fortified dairy products.