Exact Poly-K Test. Issue 7 (8th August 2016)

• Record Type: Journal Article
• Authors: Rahman, Mohammad A.; Lin, Karl K.; Tiwari, Ram C.; Jackson, Matthew
• Is Part Of: Communications in statistics. Volume 45:Issue 7(2016)
• Page Start: 2257
• Page End: 2266
• Publication Date: 2016-08-08
• Subjects: Carcinogenicity studies -- Dose response -- Exact test -- Poly-K test; Primary 62G08; Secondary 62J05; Mathematical statistics -- Periodicals; Mathematical statistics -- Data processing -- Periodicals; Digital computer simulation -- Periodicals; 519.5
• DOI: 10.1080/03610918.2014.901351
• Languages: English
• ISSNs: 0361-0918

Abstract

Abstract : For animal carcinogenicity study with multiple dose groups, positive trend test and pairwise comparisons of treated groups with control are generally performed using the Cochran-Armitage, Peto test, or Poly-K test. These tests are asymptotically normal. The exact version of Cochran-Armitage and Peto tests are available based on the permutation test assuming fixed column and row totals. For Poly-K test column totals depend on the mortality pattern of the animals and can not be kept fixed over the permutations of the animals. In this work a modification of the permutation test is suggested that can be applied on exact Poly-K test.