Analysis of Counterfeit Coated Tablets and Multi-Layer Packaging Materials Using Infrared Microspectroscopic Imaging. (12th April 2016)

• Record Type: Journal Article
• Authors: Winner, Taryn L.; Lanzarotta, Adam; Sommer, André J.
• Is Part Of: Microscopy and microanalysis. Volume 22:Number 3(2016:Jun.)
• Page Start: 649
• Page End: 655
• Publication Date: 2016-04-12
• Subjects: ATR, -- FTIR, -- counterfeit, -- packaging, -- pharmaceuticals; Microscopy -- Periodicals; Microchemistry -- Periodicals; 502.82
• DOI: 10.1017/S143192761600060X
• Languages: English
• ISSNs: 1431-9276

Abstract

Abstract: An effective method for detecting and characterizing counterfeit finished dosage forms and packaging materials is described in this study. Using attenuated total internal reflection Fourier transform infrared spectroscopic imaging, suspect tablet coating and core formulations as well as multi-layered foil safety seals, bottle labels, and cigarette tear tapes were analyzed and compared directly with those of a stored authentic product. The approach was effective for obtaining molecular information from structures as small as 6 μ m.