Adhesive durability of bone cements containing gentamicin or gentamicin/clindamycin-based antibiotics on titanium used for oral implants. Issue 19 (1st October 2016)

• Record Type: Journal Article
• Authors: Müller, Nicolas; Schmidlin, Patrick; Özcan, Mutlu
• Is Part Of: Journal of adhesion science and technology. Volume 30:Issue 19(2016)
• Page Start: 2130
• Page End: 2145
• Publication Date: 2016-10-01
• Subjects: Adhesion -- air abrasion -- antibiotic coatings -- bone cement -- implants -- peri-implantitis -- titanium; Adhesion -- Periodicals; Adhesives -- Periodicals; 668.3
• DOI: 10.1080/01694243.2016.1175254
• Languages: English
• ISSNs: 0169-4243

Abstract

Abstract: This study investigated the durability of adhesion of bone cements containing antibiotics to titanium. Titanium plates (15 mm × 15 mm × 1 mm) ( N = 80, n = 10 per group) were obtained representing oral implants. Half of the titanium plates were air-abraded (30 μm CoJet) (distance: 10 mm; pressure: 2.8 bar; duration: 15 s/cm 2 ) and silanized. They were then randomly divided into two subgroups and chemically polymerized bone cements containing either (a) gentamicin (Refobacin Bone Cement R, Biomet) (GT) or (b) gentamicin/clindamycin (Refobacin Bone Cement Revision, Biomet) (GTC) were bonded to the substrates. Half of the specimens were kept dry and the other half were thermocycled (5–55 °C, 6000 cycles). Shear force was applied to the adhesive interface until failure occurred (0.5 mm/min). Failure types were categorized considering the amount of cement on the substrate. Data (MPa) were analysed using one-, three-way ANOVAs and K-N-S tests ( α = 0.05). Two-parameter Weibull modulus, scale ( m ) and shape (0 ) were calculated. Surface conditioning ( p < 0.01) and ageing ( p < 0.01) significantly affected the results, but bone cement did not ( p > 0.05). In dry conditions, GT (without: 19.5 ± 2, with: 31.6 ± 1) showed higher bond strength than that of GTC (without: 14.1 ± 1.6, with: 20.4 ± 2.9) ( p < 0.01). Thermocycling significantly increased the results for both cements without (GT: 50 ± 3; GTC: 48.6 ± 5.6) and with air-abrasion (GT: 74 ± 1.6; GTC: 76.1 ± 2.4) ( p < 0.01). Weibull distribution presented the highest shape (0 ) for GT (Dry: 12.65; Thermocyled: 17.22). Failure types were predominantly Type 2 (46/80) (Mixed, cement remnants <¼ left on the substrate). Bone cements containing gentamicin may adhere to titanium surface more reliable but both cements benefited from air abrasion and silanization.