Exceptional biocompatibility of 3D fibrous scaffold for cardiac tissue engineering fabricated from biodegradable polyurethane blended with cellulose. Issue 14 (21st September 2016)

• Record Type: Journal Article
• Authors: Su, Wei-Fang; Ho, Chun-Chih; Shih, Tzu-Hsiang; Wang, Chen-Hua; Yeh, Chun-Hao
• Is Part Of: International journal of polymeric materials. Volume 65:Issue 14(2016)
• Page Start: 703
• Page End: 711
• Publication Date: 2016-09-21
• Subjects: Biodegradable -- cardiac -- cellulose -- polyurethane -- tissue engineering; Polymers -- Periodicals; Plastics -- Periodicals; 620.19205
• DOI: 10.1080/00914037.2016.1157802
• Languages: English
• ISSNs: 0091-4037

Abstract

ABSTRACT: The auhtors report 3D biomimetic scaffolds using polymer blend of polyurethane and cellulose for cardiac tissue engineering. The biocompatible and biodegradable polyurethane is designed, synthesized and characterized. By incorporating 10 wt% of naturally ordered cellulose into the polyurethane and electrospinning them into 3D scaffold, the scaffold exhibits good biocompatibility and mechanical property to support and accommodate constant cycles of contraction/expansion of cardiac tissue. The biocompatibility is further improved using scaffold fabricated from aligned fibers due to synergistic effects between cells and ordered macromolecules. The anisotropic structured scaffold is mimicked the extracellular matrix and has therapeutic potential in reconstruction of damaged myocardium. GRAPHICAL ABSTRACT: