DABCO-catalyzed synthesis of 3-substituted-3-hydroxyindolin-2-ones in aqueous media. Issue 7 (2nd April 2016)

• Record Type: Journal Article
• Authors: Tiwari, Keshri Nath; Bora, Darshana; Chauhan, Garima; Yadav, Deepika; Sharma, Kavita; Thakur, Ashima; Singh, Lachhman; Tripathi, Vishwadeep
• Is Part Of: Synthetic communications. Volume 46:Issue 7(2016)
• Page Start: 620
• Page End: 625
• Publication Date: 2016-04-02
• Subjects: Acetophenone -- aldol reaction -- DABCO -- hydroxyindolin-2-one -- isatin; Organic compounds -- Synthesis -- Periodicals; Chemistry, Organic; Synthesis; 547.205
• DOI: 10.1080/00397911.2016.1160411
• Languages: English
• ISSNs: 0039-7911

Abstract

ABSTRACT: An efficient and greener protocol for easy access to 3-susbstituted-3-hydroxy-2-oxindoles by the reaction with various substituted isatins and acetophenones is described. This protocol is widely applicable for a variety of isatins and acetophenones using water as a reaction media and 1, 4-diazabicyclo[2.2.2]octane (DABCO) as catalyst with shorter reaction time and good to excellent yield of products. GRAPHICAL ABSTRACT: