High-field dissolution dynamic nuclear polarization of [1-13C]pyruvic acid. Issue 18 (19th April 2016)

• Record Type: Journal Article
• Authors: Yoshihara, Hikari A. I.; Can, Emine; Karlsson, Magnus; Lerche, Mathilde H.; Schwitter, Juerg; Comment, Arnaud
• Is Part Of: Physical chemistry chemical physics. Volume 18:Issue 18(2016)
• Page Start: 12409
• Page End: 12413
• Publication Date: 2016-04-19
• Subjects: Chemistry, Physical and theoretical -- Periodicals; 541.3
• DOI: 10.1039/c6cp00589f
• Languages: English
• ISSNs: 1463-9076

Abstract

Abstract : Greater than 60% solution-state polarization of [1- 13 C]pyruvic acid polarized at 7 T and 1.0 K can be measured after rapid transfer to an MRI scanner magnet. Abstract : [1- 13 C]pyruvate is the most widely used hyperpolarized metabolic magnetic resonance imaging agent. Using a custom-built 7.0 T polarizer operating at 1.0 K and trityl radical-doped [1- 13 C]pyruvic acid, unextrapolated solution-state 13 C polarization greater than 60% was measured after dissolution and rapid transfer to a spectrometer magnet, demonstrating the signal enhancement attainable using optimized hardware. Slower rates of polarization under these conditions can be largely overcome with higher radical concentrations.