Low serotonin1B receptor binding potential in the anterior cingulate cortex in drug-free patients with recurrent major depressive disorder. (30th July 2016)

• Record Type: Journal Article
• Authors: Tiger, Mikael; Farde, Lars; Rück, Christian; Varrone, Andrea; Forsberg, Anton; Lindefors, Nils; Halldin, Christer; Lundberg, Johan
• Is Part Of: Psychiatry research. Volume 253(2016)
• Page Start: 36
• Page End: 42
• Publication Date: 2016-07-30
• Subjects: PET -- Limbic system -- Biomarker -- [11C]AZ10419369; Psychiatry -- Periodicals; Brain -- Imaging -- Periodicals; Psychiatry -- Periodicals; Diagnostic Imaging -- Periodicals; Psychiatrie -- Périodiques; Cerveau -- Imagerie pour le diagnostic -- Périodiques; 616.890754
• DOI: 10.1016/j.pscychresns.2016.04.016
• Languages: English
• ISSNs: 0925-4927

Abstract

Abstract: The pathophysiology of major depressive disorder (MDD) is not fully understood and the diagnosis is largely based on history and clinical examination. So far, several lines of preclinical data and a single imaging study implicate a role for the serotonin1B (5-HT1B ) receptor subtype. We sought to study 5-HT1B receptor binding in brain regions of reported relevance in patients with MDD. Subjects were examined at the Karolinska Institutet PET centre using positron emission tomography (PET) and the 5-HT1B receptor selective radioligand [ 11 C]AZ10419369. Ten drug-free patients with recurrent MDD and ten control subjects matched for age and sex were examined. The main outcome measure was [ 11 C]AZ10419369 binding in brain regions of reported relevance in the pathophysiology of MDD. The [ 11 C]AZ10419369 binding potential was significantly lower in the MDD group compared with the healthy control group in the anterior cingulate cortex (20% between-group difference), the subgenual prefrontal cortex (17% between-group difference), and in the hippocampus (32% between-group difference). The low anterior cingulate [ 11 C]AZ10419369 binding potential in patients with recurrent MDD positions 5-HT1B receptor binding in this region as a putative biomarker for MDD and corroborate a role of the anterior cingulate cortex and associated areas in the pathophysiology of recurrent MDD. Highlights: Low 5-HT1B receptor binding in the anterior cingulate cortex in recurrent MDD patients. Low 5-HT1B receptor binding in recurrent MDD patients also in associated areas. No other regional differences in 5-HT1B receptor brain binding in recurrent MDD.