Distinct temporal spike and local field potential activities in the thalamic parafascicular nucleus of parkinsonian rats during rest and limb movement. (25th August 2016)

• Record Type: Journal Article
• Authors: Wang, Min; Qu, Qingyang; He, Tingting; Li, Min; Song, Zhimin; Chen, Feiyu; Zhang, Xiao; Xie, Jinlu; Geng, Xiwen; Yang, Maoquan; Wang, Xiusong; Lei, Chengdong; Hou, Yabing
• Is Part Of: Neuroscience. Volume 330(2016)
• Page Start: 57
• Page End: 71
• Publication Date: 2016-08-25
• Subjects: 6-OHDA 6-hydroxydopamine -- CM/PF centromedian–parafascicular -- CV coefficient of variance -- FFT Fast Fourier Transform -- ISI interspike interval -- LFP local field potential -- PBS phosphate buffer solution -- PCA principle component analysis -- PD Parkinson's disease -- PETH perievent histogram -- TH tyrosine hydroxylase; Parkinson's disease -- thalamic parafascicular nucleus -- microelectrode -- extracellular recording -- spike -- local field potential; Neurochemistry -- Periodicals; Neurophysiology -- Periodicals; Neurology -- Periodicals; Neurochimie -- Périodiques; Neurophysiologie -- Périodiques; Neurochemistry; Neurophysiology; Electronic journals; Periodicals; Electronic journals; 612.8
• DOI: 10.1016/j.neuroscience.2016.05.031
• Languages: English
• ISSNs: 0306-4522

Abstract

Highlights: Dopamine depletion is accompanied by specific deficit in movement-related PF activity. Spike activities and LFP powers in the PF are correlated to rat behaving state. Spike activities in two PF neuronal subtypes are altered in hemiparkinsonian rats. LFP powers in special frequency in the PF are altered in hemiparkinsonian rats. Abstract: Several studies have suggested that the thalamic centromedian–parafascicular (CM/PF or the PF in rodents) is implicated in the pathophysiology of Parkinson's disease (PD). However, inconsistent changes in the neuronal firing rate and pattern have been reported in parkinsonian animals. To investigate the impact of a dopaminergic cell lesion on PF extracellular discharge in behaving rats, the PF neural activities in the spike and local field potential (LFP) were recorded in unilaterally 6-hydroxydopamine- (6-OHDA) lesioned and neurologically intact control rats during rest and limb movement. During rest, the two PF neuronal subtypes was less spontaneously active, with no difference in the spike firing rates between the control and lesioned rats; only the lesioned rats reshaped their spike firing pattern. Furthermore, the simultaneously recorded LFP in the lesioned rats exhibited a significant increase in power at 12–35 and 35–70 Hz and a decrease in power at 0.7–12 Hz. During the execution of a voluntary movement, two subtypes of PF neurons were identified by a rapid increase in the discharge activity in both the control and lesioned rats. However, dopamine lesioning was associated with a decrease in neuronal spiking fire rate and reshaping in the firing pattern in the PF. The simultaneously recorded LFP activity exhibited a significant increase in power at 12–35 Hz and a decrease in power at 0.7–12 Hz compared with the control rats. These findings indicate that 6-OHDA induces modifications in PF spike and LFP activities in rats during rest and movement and suggest that PF dysfunction may be an important contributor to the pathophysiology of parkinsonian motor impairment.