Tunable Thermal‐Sensitive Polymer–Graphene Oxide Composite for Efficient Capture and Release of Viable Circulating Tumor Cells. Issue 24 (26th April 2016)

• Record Type: Journal Article
• Authors: Yoon, Hyeun Joong; Shanker, Apoorv; Wang, Yang; Kozminsky, Molly; Jin, Qu; Palanisamy, Nallasivam; Burness, Monika L.; Azizi, Ebrahim; Simeone, Diane M.; Wicha, Max S.; Kim, Jinsang; Nagrath, Sunitha
• Is Part Of: Advanced materials. Volume 28:Issue 24(2016)
• Page Start: 4891
• Page End: 4897
• Publication Date: 2016-04-26
• Subjects: graphene oxide -- circulating tumor cell -- thermoresponsive polymer -- breast cancer -- pancreatic cancer; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201600658
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract : A highly sensitive microfluidic system to capture circulating tumor cells from whole blood of cancer patients is presented. The device incorporates graphene oxide into a thermoresponsive polymer film to serve as the first step of an antibody functionalization chemistry. By decreasing the temperature, captured cells may be released for subsequent analysis.