First-line treatment in advanced or metastatic disease: one size fits all or adapted to specific histiotypes?. Issue 4 (July 2016)

• Record Type: Journal Article
• Authors: Seddon, Beatrice
• Is Part Of: Current opinion in oncology. Volume 28:Issue 4(2016:Jul.)
• Publication Date: 2016-07
• Subjects: advanced metastatic -- chemotherapy -- first line -- histiotype -- soft tissue sarcoma; Oncology -- Periodicals; 616.994
• DOI: 10.1097/CCO.0000000000000301
• Languages: English
• ISSNs: 1040-8746

Abstract

Abstract : Purpose of review: This article evaluates the supporting evidence for adapting choice of first-line chemotherapy to specific histological subtypes in advanced or metastatic soft tissue sarcoma (STS). Recent findings: The evidence for the current standard of care for first-line chemotherapy in STS is reviewed. This is followed by an overview of the evidence for use of specific chemotherapy drugs in a number of specific STS histological subtypes. The more recent literature on newer drugs being used in the first-line setting in STS is then reviewed, and finally an assessment is made as to whether it is possible at this time to tailor first-line chemotherapy to histiotype. Summary: The review shows that at present there is insufficient evidence to support the concept of adapting choice of first-line chemotherapy in advanced or metastatic STS to specific histiotypes.