R-134a (1, 1, 1, 2-Tetrafluoroethane) Inhalation Induced Reactive Airways Dysfunction Syndrome. (May 2016)

• Record Type: Journal Article
• Authors: Doshi, Viral; Kham, Nang; Kulkarni, Shreedhar; Kapitan, Kent; Henkle, Joseph; White, Peter
• Is Part Of: American journal of therapeutics. Volume 23:Number 3(2016)
• Publication Date: 2016-05
• Subjects: R-134a -- HFA-134a -- reactive airways dysfunction syndrome -- 1, 1, 1, 2-tetrafluoroethane -- refrigerant exposure; Chemotherapy -- Periodicals; Pharmacology -- Periodicals; 615.58
• DOI: 10.1097/MJT.0000000000000124
• Languages: English
• ISSNs: 1075-2765

Abstract

Abstract : R-134a (1, 1, 1, 2-tetrafluoroethane) is widely used as a refrigerant and as an aerosol propellant. Inhalation of R-134a can lead to asphyxia, transient confusion, and cardiac arrhythmias. We report a case of reactive airways dysfunction syndrome secondary to R-134a inhalation. A 60-year-old nonsmoking man without a history of lung disease was exposed to an air conditioner refrigerant spill while performing repairs beneath a school bus. Afterward, he experienced worsening shortness of breath with minimal exertion, a productive cough, and wheezing. He was also hypoxic. He was admitted to the hospital for further evaluation. Spirometry showed airflow obstruction with an FEV1 1.97 L (45% predicted). His respiratory status improved with bronchodilators and oral steroids. A repeat spirometry 2 weeks later showed improvement with an FEV1 2.5 L (60% predicted). Six months after the incident, his symptoms had improved, but he was still having shortness of breath on exertion and occasional cough.