Combined laser in-situ keratomileusis and accelerated corneal cross-linking: an update. Issue 4 (July 2016)

• Record Type: Journal Article
• Authors: Tomita, Minoru
• Is Part Of: Current opinion in ophthalmology. Volume 27:Issue 4(2016:Jul.)
• Publication Date: 2016-07
• Subjects: accelerated collagen cross-linking -- corneal collagen crosslinking -- ectasia -- laser in-situ keratomileusis + accelerated collagen cross-linking -- laser in-situ keratomileusis Xtra -- regression; Ophthalmology -- Periodicals; Eye Diseases -- Indexes; Eye Diseases -- Periodicals; Review Literature -- Indexes; Review Literature -- Periodicals; Vision Disorders -- Indexes; Vision Disorders -- Periodicals; 617.7
• DOI: 10.1097/ICU.0000000000000281
• Languages: English
• ISSNs: 1040-8738

Abstract

Abstract : Purpose of review: The purpose is to review the literature of combined laser in-situ keratomileusis (LASIK) and accelerated corneal collagen cross-linking (CXL) in context of its indications-contraindications, kerato-refractive, visual and safety outcomes, particularly with reference to preventing the development of post-LASIK ectasia. Recent findings: LASIK + accelerated CXL has been developed with the rationale that the addition of CXL after LASIK may strengthen the LASIK compromised corneal biomechanics and minimize the complications such as post-LASIK ectasia. Different clinical studies have documented the safety and efficacy of LASIK + accelerated CXL for the correction of myopia or hyperopia and in the patients with low predicted residual bed thickness. Summary: Available literature shows that refractive and keratometric outcomes of LASIK + accelerated CXL are comparable or better than LASIK alone. Less regression has been observed after LASIK + accelerated CXL compared with LASIK alone and no case of post-LASIK ectasia development has been reported among 673 eyes with the follow-up ranging from 3 months to 4.5 years. Future studies with large numbers of patients and longer postoperative follow-ups are needed to establish the efficacy of LASIK + accelerated CXL in preventing the development of post-LASIK ectasia.