A bug's view of allergic airways disease. (June 2016)

• Record Type: Journal Article
• Authors: Hsu, Peter S.; Campbell, Dianne E.
• Is Part Of: Paediatric respiratory reviews. Volume 19(2016)
• Page Start: 69
• Page End: 74
• Publication Date: 2016-06
• Subjects: Microbiome -- Allergic airways disease -- Dysbiosis -- Prebiotic -- Probiotic; Pediatric respiratory diseases -- Periodicals; Respiratory organs -- Diseases -- Periodicals; Respiratory Tract Diseases -- Periodicals; Respiratory Therapy -- Periodicals; Child -- Periodicals; Appareil respiratoire -- Infections, chez l'enfant -- Périodiques; Appareil respiratoire -- Maladies, chez l'enfant -- Périodiques; 618.922
• DOI: 10.1016/j.prrv.2016.02.002
• Languages: English
• ISSNs: 1526-0542

Abstract

Summary: The increase in allergic airways disease has been linked to modern urbanization and lifestyle. Recent evidence suggests that the associated reduction in microbial exposure, reduction in dietary fibre intake and increased antibiotic use may cause early dysbiosis in infancy, which predisposes to immune dysregulation and allergic airways disease later in life. This implies that there may be a window of opportunity for primary prevention strategies aimed to protect or restore the microbiome early in life and thereby decrease the risk of developing allergic airways disease. Alternatively, strategies that correct dysbiosis may aid in the treatment of established allergic airways disease.