Respiratory manifestations and management in children with Common Variable Immunodeficiency. (June 2016)

• Record Type: Journal Article
• Authors: Pandit, Chetan; Hsu, Peter; van Asperen, Peter; Mehr, Sam
• Is Part Of: Paediatric respiratory reviews. Volume 19(2016)
• Page Start: 56
• Page End: 61
• Publication Date: 2016-06
• Subjects: Common variable immunodeficiency -- Diagnosis -- Respiratory management; Pediatric respiratory diseases -- Periodicals; Respiratory organs -- Diseases -- Periodicals; Respiratory Tract Diseases -- Periodicals; Respiratory Therapy -- Periodicals; Child -- Periodicals; Appareil respiratoire -- Infections, chez l'enfant -- Périodiques; Appareil respiratoire -- Maladies, chez l'enfant -- Périodiques; 618.922
• DOI: 10.1016/j.prrv.2015.12.003
• Languages: English
• ISSNs: 1526-0542

Abstract

Summary: Common variable immunodeficiency is an antibody deficiency that usually presents in childhood with recurrent sino-pulmonary infections. Diagnostic delay is frequent and thus respiratory morbidity is common, ranging from recurrent suppurative bronchitis to bronchiectasis. Immunoglobulin replacement therapy is the mainstay of treatment, whilst prophylactic antibiotic therapy and muco-ciliary clearance are additional treatment options. This review examines the diagnosis and management of respiratory issues in children with CVID.