NMDA receptors are involved in the antidepressant-like effects of capsaicin following amphetamine withdrawal in male mice. (4th August 2016)

• Record Type: Journal Article
• Authors: Amiri, Shayan; Alijanpour, Sakineh; Tirgar, Fatemeh; Haj-Mirzaian, Arya; Amini-Khoei, Hossein; Rahimi-Balaei, Maryam; Rastegar, Mojgan; Ghaderi, Marzieh; Ghazi-Khansari, Mahmoud; Zarrindast, Mohammad-Reza
• Is Part Of: Neuroscience. Volume 329(2016)
• Page Start: 122
• Page End: 133
• Publication Date: 2016-08-04
• Subjects: AW amphetamine withdrawal -- FST forced swimming test -- MK-801 dizocilpine -- NMDA N-Methyl-d-aspartate -- OFT open-field test -- TRPV1 transient receptor potential cation channel, subfamily V, member 1; amphetamine withdrawal -- depression -- TRPV1 -- NMDA receptors -- FST -- splash test; Neurochemistry -- Periodicals; Neurophysiology -- Periodicals; Neurology -- Periodicals; Neurochimie -- Périodiques; Neurophysiologie -- Périodiques; Neurochemistry; Neurophysiology; Electronic journals; Periodicals; Electronic journals; 612.8
• DOI: 10.1016/j.neuroscience.2016.05.003
• Languages: English
• ISSNs: 0306-4522

Abstract

Highlights: AW induced depressive-like behaviors in male adult mice. Activation of TRPV1 by capsaicin provoked antidepressant-like effects in AW mice. NMDA receptor blockade by MK-801 attenuated depressive-like behaviors in AW mice. NMDA receptors play a role in antidepressant-like effects of capsaicin in AW mice. Abstract: Amphetamine withdrawal (AW) is accompanied by diminished pleasure and depression which plays a key role in drug relapse and addictive behaviors. There is no efficient treatment for AW-induced depression and underpinning mechanisms were not well determined. Considering both transient receptor potential cation channel, subfamily V, member 1 (TRPV1) and N -Methyl-d -aspartate (NMDA) receptors contribute to pathophysiology of mood and addictive disorders, in this study, we investigated the role of TRPV1 and NMDA receptors in mediating depressive-like behaviors following AW in male mice. Results revealed that administration of capsaicin, TRPV1 agonist, (100 μg/mouse, i.c.v.) and MK-801, NMDA receptor antagonist (0.005 mg/kg, i.p.) reversed AW-induced depressive-like behaviors in forced swimming test (FST) and splash test with no effect on animals' locomotion. Co-administration of sub-effective doses of MK-801 (0.001 mg/kg, i.p.) and capsaicin (10 μg/mouse, i.c.v) exerted antidepressant-like effects in behavioral tests. Capsazepine, TRPV1 antagonist, (100 μg/mouse, i.c.v) and NMDA, NMDA receptor agonist (7.5 mg/kg, i.p.) abolished the effects of capsaicin and MK-801, respectively. None of aforementioned treatments had any effect on behavior of control animals. Collectively, our findings showed that activation of TRPV1 and blockade of NMDA receptors produced antidepressant-like effects in male mice following AW, and these receptors are involved in AW-induced depressive-like behaviors. Further, we found that rapid antidepressant-like effects of capsaicin in FST and splash test are partly mediated by NMDA receptors.