Endothelin 1, ADMA and SDMA in pregnancies with obstetric and thrombotic antiphospholipid syndrome. (August 2016)

• Record Type: Journal Article
• Authors: Mayer-Pickel, K.; Kolovetsiou-Kreiner, V.; Mörtl, M.G.; Schlembach, D.; Eberhard, K.; Obermayer-Pietsch, B.; Lang, U.; Cervar-Zivkovic, M.
• Is Part Of: Journal of reproductive immunology. Volume 116(2016)
• Page Start: 86
• Page End: 92
• Publication Date: 2016-08
• Subjects: Reproduction -- Immunological aspects -- Periodicals; Immunology -- Periodicals; Allergy and Immunology -- Periodicals; Reproduction -- Periodicals; Reproduction -- Immunologie -- Périodiques; Immunologie -- Périodiques; Immunology; Reproduction -- Immunological aspects; Periodicals; Electronic journals; Electronic journals; 615.766
• DOI: 10.1016/j.jri.2016.05.006
• Languages: English
• ISSNs: 0165-0378

Abstract

Highlights: The increased levels of ET-1, ADMA and SDMA support the theory of inflammation as part of the pathophysiology in Antiphospholipid Syndrome. These anti-angiogenic factors with impaired angiogenesis might give a new insight in the mechanisms of adverse obstetric outcome in APS. It seems that even if OAPS and TPS are two different clinical entities, the dimension of aPl-induced endothelial dysfunction is similar.