Long non-coding RNAs as novel therapeutic targets in cancer. (August 2016)

• Record Type: Journal Article
• Authors: Lavorgna, Giovanni; Vago, Riccardo; Sarmini, Mohamad; Montorsi, Francesco; Salonia, Andrea; Bellone, Matteo
• Is Part Of: Pharmacological research. Volume 110(2016:Aug.)
• Page Start: 131
• Page End: 138
• Publication Date: 2016-08
• Subjects: ncRNA -- Cancer -- Bioinformatics -- Drug delivery -- Apoptosis; Pharmacology -- Periodicals; Pharmacology -- Periodicals; Research -- Periodicals; Médicaments -- Recherche -- Périodiques; Pharmacologie -- Périodiques; 615.105
• DOI: 10.1016/j.phrs.2016.05.018
• Languages: English
• ISSNs: 1043-6618

Abstract

Graphical abstract: Abstract: Thanks to impressive technology advancements, pervasive expression of non-coding RNAs (ncRNAs) has been recently identified in the genome of numerous cancers. Long ncRNAs (lncRNAs) belong to a new class of ncRNAs including tens of thousands different species. A fraction of these molecules shows a striking cancer-enriched expression pattern, suggesting an essential role in tumor cells and, possibly, a utility in therapeutic terms. This review aims at summarizing current knowledge for the identification and validation of lncRNAs as therapeutics targets in tumors. Both in-silico and wet-biology resources are presented in relation to the many challenges that the scientific community still needs to address in terms of lncRNA identification, stratification, patient personalization, drug delivery and toxicity.