Implications of MDSCs-targeting in lung cancer chemo-immunotherapeutics. (August 2016)

• Record Type: Journal Article
• Authors: Adah, Dickson; Hussain, Muzammal; Qin, Limei; Qin, Li; Zhang, Jiancun; Chen, Xiaoping
• Is Part Of: Pharmacological research. Volume 110(2016:Aug.)
• Page Start: 25
• Page End: 34
• Publication Date: 2016-08
• Subjects: Ad adenoviral -- ARG arginase -- ATRA all-trans-retinoic acid -- CAIX carbonic anhydrase IX -- CDK cyclin-dependent kinase -- CTLs cytotoxic T lymphocytes -- DCs dendritic cells -- EGFR epidermal growth factor receptor -- G-CSF granulocyte colony-stimulating factor -- GM-CSF granulocyte monocyte colony stimulating factor -- ICTIs inflammatory cellular tumor infiltrates -- IL interleukin -- IL-2Rβ IL-2 receptor beta -- iNOS inducible nitric oxide synthase -- IFN-γ interferon gamma -- MDSCs myeloid-derived suppressor cells -- MHC major histocompatibility complex -- MMP matrix metalloproteinase -- NF-κB nuclear factor kappa-light-chain-enhancer of activated B cells -- NK natural killer -- NO nitric oxide -- NSCLC non-small cell lung cancer -- ORR overall response rate -- PDGFR platelet-derived growth factor receptor -- PFS progression-free survival -- PGE2 prostaglandin E2 -- ROS reactive oxygen species -- SCLC small cell lung cancer -- TAM tumor-associated macrophages -- TGFβ transforming growth factor-beta -- TNFα tumor necrosis factor-α -- Tregs regulatory T cells -- VEGFR vascular endothelial growth receptor; Anticancer -- Chemo-immunotherapy -- Lung cancer -- NSCLC -- SCLC -- MDSCs; Pharmacology -- Periodicals; Pharmacology -- Periodicals; Research -- Periodicals; Médicaments -- Recherche -- Périodiques; Pharmacologie -- Périodiques; 615.105
• DOI: 10.1016/j.phrs.2016.05.007
• Languages: English
• ISSNs: 1043-6618

Abstract

Graphical abstract: Abstract: Despite advances in chemotherapy and immunotherapy, advanced lung cancer remains an incurable disease. Novel trends in anticancer therapeutics focus on harnessing the therapeutically-targeted tumor-related immune suppression. In this respect, myeloid-derived suppressor cells (MDSCs) have captured considerable attention in the last few years, as they are vividly implicated in tumor immune escape mechanisms. In this review, we specifically discuss the multifaceted roles of MDSCs in lung tumor microenvironment, encompassing lung tumor growth and progression via suppression of anti-tumor immunity, association with worse prognosis, and hampering the efficacy of lung cancer chemotherapy and immunotherapy. In addition, we also discuss that therapeutic manipulation of MDSCs-targeting, either alone or in combination with chemo- and/or immune-therapeutic regimens, may not only have tumor growth inhibition, anti-angiogenesis and anti-metastasis effects, but may also have the potential to enhance the efficacy of lung cancer chemotherapy and immunotherapy.