Longitudinal analysis of mature breastmilk and serum immune composition among mixed HIV-status mothers and their infants. Issue 4 (August 2016)

• Record Type: Journal Article
• Authors: Pedersen, Sarah H.; Wilkinson, Amanda L.; Andreasen, Aura; Kinung'hi, Safari M.; Urassa, Mark; Michael, Denna; Todd, Jim; Changalucha, John; McDermid, Joann M.
• Is Part Of: Clinical nutrition. Volume 35:Issue 4(2016:Aug.)
• Page Start: 871
• Page End: 879
• Publication Date: 2016-08
• Subjects: Africa -- Breastfeeding -- Cytokine -- Immunoglobulin -- Immunology -- Stunting; BMI body mass index -- IFN interferon -- Ig immunoglobulin -- IL interleukin -- IQR interquartile range -- LOD limit of detection -- SD standard deviation -- TNF tumor necrosis factor -- WHO World Health Organization; Critically ill -- Nutrition -- Periodicals; Diet therapy -- Periodicals; Parenteral feeding -- Periodicals; Enteral feeding -- Periodicals; Enteral Nutrition -- Periodicals; Parenteral Nutrition -- Periodicals; Metabolism -- Periodicals; Diétothérapie -- Périodiques; Alimentation parentérale -- Périodiques; Alimentation entérale -- Périodiques; Nutrition -- Périodiques; Diet therapy; Enteral feeding; Nutrition; Parenteral feeding; Electronic journals; Periodicals; Electronic journals; 615.854
• DOI: 10.1016/j.clnu.2015.05.016
• Languages: English
• ISSNs: 0261-5614

Abstract

Summary: Background & aims: Understanding mature breastmilk immunology may benefit infants chronically exposed to infectious pathogens in resource-limited regions. Methods: This prospective rural/semi-rural Tanzanian cohort of women (n = 102 at delivery; 38% HIV-positive) and their infants (n = 102) investigated breastmilk, maternal and infant serum immunoglobulins (IgA/IgG1–4 /IgM) and cytokines (IL-1β/IL-2/IL-6/IL-10/IL-12p70/IL-13/IL-15/TNF-α/IFN-γ) at 1, 2, 3, 6-months postpartum. Results: Milk immunoglobulins followed an inverse U-shaped pattern, while cytokine patterns were mixed. Exclusive breastfeeding duration and feeding intensity were associated with greater breastmilk total immunoglobulin and IgA, IgG1-3 and IL-12p70 concentrations. Maternal mastitis, fever or cough was associated with higher breastmilk total cytokine concentrations, while infant fever was associated with lower milk immunoglobulins or cytokines. Strong (r ≥ 0.40) to weak (r = 0.20–0.29) positive correlations between maternal serum-breastmilk or breastmilk-infant serum immunoglobulins were evident. Breastmilk cytokines were moderate to weakly negatively correlated with infant serum. Breastmilk immunology did not differ by maternal malnutrition or HIV-seropositivity. Conclusions: Mature breastmilk is a dynamic source of many specific and non-specific immune factors associated with maternal and infant health and infant nutrition. Breastfeeding practices are associated with differential breastmilk immunological composition providing immunological support for universal recommendations to exclusively breastfeed for 6-months. Highlights: Humoral and immune molecule composition varies over time in mature breastmilk. Mature milk immune composition did not differ by maternal HIV-seropositivity alone. Exclusive breastfeeding practice is associated with more immune-concentrated milk. Few exclusive breastfeed to 6-months; infant feeding education and support needed. Observations immunologically support WHO infant feeding recommendations and goals.