Cucurbitane-type triterpenoids from the aerial parts of Momordica charantia L. (June 2016)

• Record Type: Journal Article
• Authors: Jiang, Ying; Peng, Xing-Rong; Yu, Mu-Yuan; Wan, Luo-Sheng; Zhu, Guo-Lei; Zhao, Gao-Ting; Zhou, Lin; Qiu, Ming-Hua; Liu, Jian
• Is Part Of: Phytochemistry letters. Volume 16(2016:Jun.)
• Page Start: 164
• Page End: 168
• Publication Date: 2016-06
• Subjects: Momordica -- Momordica charantia L. -- Cucurbitane-type triterpenoids; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2016.04.007
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: Six new cucurbitane-type triterpenoids were isolated from the stems and leaves of Momordica charantia L. Compounds2 and3 were a pair of 19-isomers. The structures of new compounds were successfully determined by extensive MS, 1D, 2D NMR spectroscopic technologies. Abstract: Six new cucurbitane-type triterpenoids (1 –6 ), together with two known analogues (7 and8 ) were isolated from the aerial parts of Momordica charantia L. The structures of new compounds were identified as cucurbita-6, 24-dien-3β, 23-diol-19, 5β-olide (1 ), (19 R )-5β, 19-epoxy-19-methoxycucurbita-6, 24-dien-3β, 23-diol (2 ), (19 S )-5β, 19-epoxy-19-methoxycucurbita-6, 24-dien-3β, 23-diol (3 ), (19 R )-5β, 19-epoxy-19-isopropoxycucurbita-6, 24-dien-3β, 23-diol (4 ), 3β, 23-dihydroxy-5-methoxycucurbita-6, 24-dien-19-al (5 ) and (19 R )-7β, 19-epoxy-19-methoxycucurbita-5, 24-dien-3β, 23-diol (6 ), by extensive MS, 1D and 2D NMR spectroscopic technologies. This is the first report of the isolation of tetracyclic triterpenoids possessing a 7β, 19-epoxy system, viz., 6, from M. charantia L.