Isolation and identification of oxygenated lanostane-type triterpenoids from the fungus Ganoderma lucidum. (June 2016)

• Record Type: Journal Article
• Authors: Zhao, Xi-Run; Zhang, Bao-Jing; Deng, Sa; Zhang, Hou-Li; Huang, Shan-Shan; Huo, Xiao-Kui; Wang, Chao; Liu, Fang; Ma, Xiao-Chi
• Is Part Of: Phytochemistry letters. Volume 16(2016:Jun.)
• Page Start: 87
• Page End: 91
• Publication Date: 2016-06
• Subjects: Ganoderma lucidum -- Lanostane -- Triterpenoids; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2016.03.007
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: Four compounds were obtained from the CHCl3 extract of the fruiting body of G. lucidum by various chromatographic technologies. The isolated triterpenoids were identified as new highly oxygenated lanostane type triterpenoids. For compound1, there is a rare five member lactone ring in the structure. Abstract: Ganoderma lucidum is widely used throughout the world as a form of traditional medicine. Phytochemical investigation of the chloroform (CHCl3 ) extract of the fruiting body of G. lucidum resulted in the isolation of four lanostane-type triterpenoids. Based on various spectroscopic data, the isolated triterpenoids were identified as highly oxygenated lanostane-type triterpenoids, including four new compounds (1 –4 ). Furthermore, in vitro bioassays using an adriamycin (ADM)-resistant human breast adenocarcinoma cell line (MCF-7/ADR) and measuring the nitric oxide production in LPS-stimulated macrophages showed that the isolated triterpenoids had no inhibitory effects on p -glycoprotein ( p -gp).