2, 2, 2-Trifluoroethanol activated one-pot Mannich-like reaction of β-nitroenamines, secondary amines, and aromatic aldehydes. Issue 25 (22nd June 2016)

• Record Type: Journal Article
• Authors: Han, Li; Feng, Yian; Luo, Ming; Yuan, Zihao; Shao, Xusheng; Xu, Xiaoyong; Li, Zhong
• Is Part Of: Tetrahedron letters. Volume 57:Issue 25(2016)
• Page Start: 2727
• Page End: 2731
• Publication Date: 2016-06-22
• Subjects: 2, 2, 2-Trifluoroethanol -- β-Nitroenamines -- Mannich-like reaction -- One-pot reaction; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2016.05.023
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: A unique and efficient one-pot reaction of β-nitroenamines, secondary amines, and aromatic aldehydes. 2, 2, 2-Trifluoroethanol (TFEA) was used to activate this reaction. Afford the desired Mannich-like products in moderate to excellent yields with wide substrate scopes. Abstract: A unique and efficient 2, 2, 2-trifluoroethanol-activated one-pot reaction of β-nitroenamines, secondary amines and aromatic aldehydes was developed under mild and convenient conditions. In the presence of 2, 2, 2-trifluoroethanol (TFEA), aromatic aldehydes were activated by hydrogen bonding with TFEA. The newly-developed reaction could afford the desired Mannich-like products in moderate to excellent yields with wide substrate scopes.