Ageloline A, new antioxidant and antichlamydial quinolone from the marine sponge-derived bacterium Streptomyces sp. SBT345. Issue 25 (22nd June 2016)

• Record Type: Journal Article
• Authors: Cheng, Cheng; Othman, Eman M.; Reimer, Anastasija; Grüne, Matthias; Kozjak-Pavlovic, Vera; Stopper, Helga; Hentschel, Ute; Abdelmohsen, Usama R.
• Is Part Of: Tetrahedron letters. Volume 57:Issue 25(2016)
• Page Start: 2786
• Page End: 2789
• Publication Date: 2016-06-22
• Subjects: Sponges -- Streptomyces sp. -- Chlorinated quinolone -- Chlamydia trachomatis; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2016.05.042
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: A new chlorinated quinolone was isolated from the sponge-associated Streptomyces sp. SBT345. Ageloline A showed antioxidant potential. Ageloline A inhibited the formation and growth of Chlamydia trachomatis . Abstract: A new chlorinated quinolone, ageloline A, was isolated from the broth culture of Streptomyces sp. SBT345 that was cultivated from the Mediterranean sponge Agelas oroides . The structure of this compound was determined by spectroscopic analysis including 1D and 2D NMR as well as HR-ESI-MS experiments. Ageloline A exhibited antioxidant potential using cell-free and cell-based assays and was further able to reduce oxidative stress and genomic damage induced by the oxidative stress inducer 4-nitroquinoline-1-oxide (NQO). Moreover, ageloline A inhibited the formation and growth of Chlamydia trachomatis inclusion in a dose-dependent manner with an IC50 value of 9.54 ± 0.36 μM. Interestingly, experimental data showed that the antichlamydial activity of ageloline A might be related to its antioxidant potential. These results demonstrate that sponge-associated actinomycetes are rich sources for natural products with new pharmacological activities and relevance to drug discovery.