The atrial natriuretic peptide (ANP) knockout mouse does not exhibit the phenotypic features of pre-eclampsia or demonstrate fetal growth restriction. (June 2016)

• Record Type: Journal Article
• Authors: Finn-Sell, Sarah L.; Renshall, Lewis J.; Cowley, Elizabeth J.; Dilworth, Mark R.; Wareing, Mark; Greenwood, Susan L.; Sibley, Colin P.; Cottrell, Elizabeth C.
• Is Part Of: Placenta. Volume 42(2016:Jun.)
• Page Start: 25
• Page End: 27
• Publication Date: 2016-06
• Subjects: Pre-eclampsia -- Fetal growth restriction -- Atrial natriuretic peptide -- Mouse; Placenta -- Periodicals; Reproduction -- Periodicals; Placenta -- Periodicals; Placenta -- Périodiques; Reproduction -- Périodiques; 612.63
• DOI: 10.1016/j.placenta.2016.04.003
• Languages: English
• ISSNs: 0143-4004

Abstract

Abstract: The ANP knockout mouse is reported to exhibit pregnancy-associated hypertension, proteinuria and impaired placental trophoblast invasion and spiral artery remodeling, key features of pre-eclampsia (PE). We hypothesized that these mice may provide a relevant model of human PE with associated fetal growth restriction (FGR). Here, we investigated pregnancies of ANP wild type (ANP +/+ ), heterozygous (ANP +/- ) and knockout (ANP −/- ) mice. Maternal blood pressure did not differ between genotypes (E12.5, E17.5), and fetal weight (E18.5) was unaffected. Placental weight was greater in ANP −/− versus ANP +/+ mice. Therefore, in our hands, the ANP model does not express phenotypic features of PE with FGR. Highlights: Mouse models of pre-eclampsia and fetal growth restriction are needed to test potential therapies. ANP knockout mice have previously been identified as a potential model of pre-eclampsia. We find that these mice do not exhibit pregnancy-associated hypertension, or fetal growth restriction. ANP knockout mice do not provide a robust model of pre-eclampsia or fetal growth restriction.