Low immune cell ARA and high plasma 12-HETE and 17-HDHA in iron-deficient South African school children with allergy. (July 2016)

• Record Type: Journal Article
• Authors: Malan, L.; Baumgartner, J.; Calder, P.C.; Smuts, C.M.
• Is Part Of: Prostaglandins, leukotrienes, and essential fatty acids. Volume 110(2016:Jul.)
• Page Start: 35
• Page End: 41
• Publication Date: 2016-07
• Subjects: ARA arachidonic acid -- cPLA2 cytosolic phospholipase 2 -- D5D delta-5 desaturase -- D6D delta-6 desaturase -- DGLA dihomo-gamma-linolenic acid -- DHA docosahexaenoic acid -- EPA eicosapentaenoic acid -- FADS fatty acid desaturase -- FAME fatty acid methyl ester -- HDHA hydroxydocosahexaenoic acid -- HEPE hydroxyeicosapentaenoic acid -- HETE hydroxyeicosatetraenoic acid -- ISAAC International Study on Asthma and Allergy in Childhood -- LA linoleic acid -- LCPUFA long-chain polyunsaturated fatty acid -- PBMC peripheral blood mononuclear cells -- PD1 protectin D1 -- PUFA polyunsaturated fatty acid -- RvD1 resolvin D1 -- tIgE total immunoglobulin E; Allergy -- Fatty acid composition -- Arachidonic acid -- Lipid mediator -- Inflammation -- Inflammation-resolving; Lipids -- Periodicals; Unsaturated fatty acids -- Periodicals; Prostaglandins -- Periodicals; Leukotrienes -- Periodicals; Fatty Acids, Unsaturated -- Periodicals; Acides gras insaturés -- Périodiques; Prostaglandines -- Périodiques; Leucotriènes -- Périodiques; Lipides -- Périodiques; 612.01577
• DOI: 10.1016/j.plefa.2016.05.006
• Languages: English
• ISSNs: 0952-3278

Abstract

Abstract: Allergy has been associated with altered fatty acid and inflammatory status. In this cross-sectional study of 321 rural iron deficient (ID) South African children (aged 6–11 years), a subsample (n=111) of children with parent-reported allergy data were divided into an allergic (n=30) and non-allergic (n=81) group and compared. PBMC arachidonic acid (ARA; P =0.010) and the PBMC ARA to dihomo-gamma-linolenic acid (DGLA) ratio ( P =0.035) were lower in the allergic children. Plasma 12-hydroxyeicosatetraenoic acid and 17-hydroxydocosahexaenoic acid (17-HDHA) were higher ( P =0.040 and 0.020, respectively) in the allergic group. Thus, a fatty acid composition and lipid mediator levels indicative of increased release of ARA from PBMC membranes, increased inflammation as well as the resolving thereof, were associated with parent-reported allergy symptoms. This study used baseline data of an intervention study which was registered at clinicaltrials.gov as NCT01092377. Highlights: Total phospholipid ARA in PBMC was lower in allergic children. Plasma 12-HETE and 17-HDHA were higher in allergic children. A fatty acid composition and lipid mediator levels indicative of increased release of ARA from PBMC membranes, increased inflammation as well as the resolving thereof, were associated with parent-reported allergy symptoms.