Reducing dietary intake of linoleic acid of mouse dams during lactation increases offspring brain n-3 LCPUFA content. (July 2016)

• Record Type: Journal Article
• Authors: Schipper, L.; Oosting, A.; Scheurink, A.J.W.; van Dijk, G.; van der Beek, E.M.
• Is Part Of: Prostaglandins, leukotrienes, and essential fatty acids. Volume 110(2016:Jul.)
• Page Start: 8
• Page End: 15
• Publication Date: 2016-07
• Subjects: ARA arachidonic acid -- ALA α-linolenic acid -- CTR control diet -- DHA docosahexaenoic acid -- DPA docosapentaenoic acid -- EPA eicosapentaenoic acid -- N3LCP diet with a relative increase in n-3 FA -- LA linoleic acid -- LCPUFA long-chain polyunsaturated fatty acids -- LowLA diet with relative reduction in n-6 FA -- MUFA monounsaturated fatty acids -- P postnatal day -- PUFA polyunsaturated fatty acids -- SFA saturated fatty acids; Linoleic acid -- n-3 Long chain polyunsaturated fatty acids -- Maternal diet -- Milk -- Brain development; Lipids -- Periodicals; Unsaturated fatty acids -- Periodicals; Prostaglandins -- Periodicals; Leukotrienes -- Periodicals; Fatty Acids, Unsaturated -- Periodicals; Acides gras insaturés -- Périodiques; Prostaglandines -- Périodiques; Leucotriènes -- Périodiques; Lipides -- Périodiques; 612.01577
• DOI: 10.1016/j.plefa.2016.05.001
• Languages: English
• ISSNs: 0952-3278

Abstract

Abstract: Omega (n-)3 and n-6 long chain polyunsaturated fatty acids (LCPUFA) accumulation in the infant brain after birth is strongly driven by dietary supply of n-3 and n-6 LCPUFAs and their C18 precursors through breast milk or infant formula. n-3 LCPUFA accretion is associated with positive effects on neurodevelopmental outcome whereas high n-6 LCPUFA accumulation is considered disadvantageous. Maternal diet is crucial for breast milk fatty acid composition. Unfortunately, global increases in linoleic acid (C18:2n-6; LA) intake have dramatically increased n-6 LCPUFA and reduced n-3 LCPUFA availability for breastfed infants. We investigated the effects of reducing maternal dietary LA, or increasing n-3 LCPUFA, during lactation on milk and offspring brain fatty acids in mice. Offspring brain n-3 LCPUFA was higher following both interventions, although effects were mediated by different mechanisms. Because of competitive interactions between n-3 and n-6 fatty acids, lowering maternal LA intake may support neurodevelopment in breastfed infants. Highlights: Reducing maternal dietary LA results in lower milk LA content. Increasing maternal dietary n-3 LCPUFA increases milk n-3 LCPUFA content. Offspring brain n-3 LCPUFA was higher following both interventions.