Four hepatosplenic T-cell lymphoma cases of Japanese patients. (2016)

• Record Type: Journal Article
• Authors: Kawai, Hidetsugu; Matsushita, Hiromichi; Ohmachi, Ken; Kojima, Minoru; Machida, Shinichiro; Ogawa, Yoshiaki; Kawada, Hiroshi; Nakamura, Naoya; Ando, Kiyoshi
• Is Part Of: Leukemia research reports. Volume 5(2016)
• Page Start: 3
• Page End: 6
• Publication Date: 2016
• Subjects: Hepatosplenic T-cell lymphoma -- Immunodeficiency -- Elderly patients; Leukemia -- Periodicals; Lymphomas -- Periodicals; Multiple myeloma -- Periodicals; Leukemia -- Periodicals; Lymphoma -- Periodicals; Multiple Myeloma -- Periodicals; Hematologic Neoplasms -- Periodicals; Leukemia; Lymphomas; Multiple myeloma; Electronic journals; Periodicals; 616.9941905
• DOI: 10.1016/j.lrr.2015.12.001
• Languages: English
• ISSNs: 2213-0489

Abstract

Abstract: Hepatosplenic T-cell lymphoma (HSTCL), a rare type of γδ T-cell lymphoma, is characterized by hepatosplenomegaly and cytopenias. It is associated with immunodeficiency and its age of onset is reportedly between the 20s and 30s. We herein report 4 Japanese HSTCL cases. Three of them, including an elderly case that was 74 years of age, were not at adolescence. No cases had a history of immunodeficiency. All other disease phenotypes were similar to the typical HSTCL cases. These findings suggest that there are a certain proportion of HSTCL patients who presented after middle age. Highlights: Three out of four HSTCL cases in a Japanese institute were over 59 years of age. None of the patients had previous illness that was related to immunodeficiency. There may be a certain proportion of HSTCL patients who presented after middle age.