Overexpression of tissue microRNA10b may help predict glioma prognosis. (July 2016)

• Record Type: Journal Article
• Authors: Zhang, Xinxin; Cheng, Jian; Fu, Ling; Li, Qingshui
• Is Part Of: Journal of clinical neuroscience. Volume 29(2016:Jul.)
• Page Start: 59
• Page End: 63
• Publication Date: 2016-07
• Subjects: Glioma -- microRNA-10b -- miR-10b -- Prognosis -- RT-PCR; Brain -- Surgery -- Periodicals; Neurosciences -- Periodicals; Nervous system -- Surgery -- Periodicals; Brain -- surgery -- Periodicals; Neurosurgical Procedures -- Periodicals; Neurosciences -- Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.jocn.2015.10.046
• Languages: English
• ISSNs: 0967-5868

Abstract

Highlights: Expression of miR-10b was significantly higher in glioma than normal tissues. Overexpression of miR-10b was an independent prognositic factor for glioma. MiR-10b was related to poor overall survival in high grade glioma patients. Abstract: We investigated the relationship between microRNA-10b (miR-10b) expression and prognosis in human glioma patients. Quantitative real-time polymerase chain reaction (qRT-PCR) analysis was used to characterize the expression patterns of miR-10b in 128 glioma and 20 normal brain tissues. Clinical information – age, sex, Karnofsky Performance Status (KPS) and World Health Organization (WHO) grade – were also collected. The associations between miR-10b expression and the clinicopathological factors and outcome of glioma patients were statistically analyzed. Expression levels of miR-10b in glioma tissue were significantly higher than in normal brain tissue (P < 0.001). High-grade glioma (WHO grade III and IV) had much higher miR-10b expression levels than low-grade tumors (WHO grade I and II). Additionally, the increased miR-10b expression in the glioma tissues was significantly associated with a low KPS (P = 0.03). Kaplan–Meier survival curves and Cox regression analyses showed that overexpression of miR-10b (P = 0.01) and high grade (P = 0.02) were independent factors predicting poor outcome for glioma patients. Furthermore, subgroup analyses showed that the miR-10b expression level was significantly associated with poor overall survival in glioma patients with high grades (P < 0.001). Up-regulation of miR-10b may have value in predicting clinical outcome in glioma patients, particularly for those with high pathological grades.