Left ventricular remodelling changes without concomitant loss of myocardial fat after long-term dietary intervention. (1st August 2016)

• Record Type: Journal Article
• Authors: Andersson, Jonas; Mellberg, Caroline; Otten, Julia; Ryberg, Mats; Rinnström, Daniel; Larsson, Christel; Lindahl, Bernt; Hauksson, Jon; Johansson, Bengt; Olsson, Tommy
• Is Part Of: International journal of cardiology. Volume 216(2016)
• Page Start: 92
• Page End: 96
• Publication Date: 2016-08-01
• Subjects: BP blood pressure -- CO cardiac output -- EDV end-diastolic volume -- EF ejection fraction -- ESV end-systolic volume -- LVM left ventricle mass -- MR magnetic resonance -- MTG myocardial triglyceride -- NNR Nordic Nutrition Recommendations -- PD Palaeolithic diet; Cardiac Magnetic Resonance (CMR) imaging -- Diet -- Metabolic heart disease -- Obesity -- Weight reduction; Cardiology -- Periodicals; Electronic journals; 616.12
• DOI: 10.1016/j.ijcard.2016.04.050
• Languages: English
• ISSNs: 0167-5273

Abstract

Abstract: Background: Accumulation of myocardial triglycerides (MTG) is associated with impaired left ventricular (LV) remodelling and function in obese and diabetic subjects. The role of MTG accumulation in development of heart failure in this group of patients is unknown. Short-term studies suggest that diets that lead to weight loss could mobilize MTG, with a favourable effect on cardiac remodelling. In a 24-month, randomized, investigator-blinded study, we assessed the effect of two different diets and subsequent weight loss on cardiac function and MTG in postmenopausal women. Methods: Sixty-eight healthy postmenopausal women with body mass index [BMI] ≥ 27 kg/m 2 were randomized to an ad libitum Palaeolithic diet (PD) or a Nordic Nutrition Recommendation (NNR) diet for 24 months. Morphology, cardiac function, and MTG levels were measured using magnetic resonance (MR) scanning, including proton spectroscopy at baseline and 6 and 24 months. Results: Despite mean weight losses of 4.9 (1.0) kg (NNR) and 7.8 (1.1) kg (PD), the MTG content did not change over time (p = 0.98 in the NNR and p = 0.11 in the PD group at 24 months). Reduced left ventricular mass was observed in both diet groups over 24 months. Blood pressure was reduced at 6 months, but returned to baseline levels at 24 months. End diastolic volume, stroke volume, and cardiac output decreased over time. No differences between diet groups were observed. Conclusions: Diet intervention and moderate weight loss over 24 months improved LV remodelling but did not alter MTG levels in overweight/obese postmenopausal women.