The effect of intrathecal baclofen treatment on activities of daily life in children and young adults with cerebral palsy and progressive neurological disorders. (July 2016)

• Record Type: Journal Article
• Authors: Bonouvrié, Laura; Becher, Jules; Soudant, Dan; Buizer, Annemieke; van Ouwerkerk, Willem; Vles, Georges; Vermeulen, R. Jeroen
• Is Part Of: European journal of paediatric neurology. Volume 20:Number 4(2016:Jul.)
• Page Start: 538
• Page End: 544
• Publication Date: 2016-07
• Subjects: Baclofen -- Child -- Cerebral palsy -- Nervous system diseases -- Muscle spasticity -- Dystonia; ADL activities of daily life -- CP cerebral palsy -- DCP dystonic cerebral palsy -- F female -- GMFCS gross motor function classification system -- ITB intrathecal baclofen -- M male -- N number -- PND progressive neurological disease -- SCP spastic cerebral palsy -- SD standard deviation -- VAS visual analogue scale -- yrs years; Pediatric neurology -- Periodicals; Nervous System Diseases -- Periodicals; Child -- Periodicals; Infant -- Periodicals; Neurologie pédiatrique -- Périodiques; Pediatric neurology; Electronic journals; Periodicals; Electronic journals; 618.928
• DOI: 10.1016/j.ejpn.2016.02.013
• Languages: English
• ISSNs: 1090-3798

Abstract

Abstract: Introduction: Intrathecal baclofen (ITB) treatment is applied in patients with spastic cerebral palsy (SCP), dystonic cerebral palsy (DCP) and progressive neurological disease (PND). Our aim was to investigate whether ITB treatment has a different effect on activities of daily life (ADL) in these groups. Method: A retrospective and cross-sectional survey was conducted using a questionnaire to assess the qualitative effect of ITB (Likert scale) on different domains of functioning (mobility, personal care, communication, comfort) and satisfaction with the results. Groups were compared using non-parametric statistics. Results: Questionnaires were completed for 68 patients (39 SCP, 13 DCP, 16 PND). Satisfaction scores were relatively high in all groups (7–8) and the positive effect on personal care and communication was similar in all groups. The PND group had the shortest follow-up and scored significantly less favourably for the effect on mobility and comfort. Discussion: This is the first study to show that ITB treatment has similar effects on personal care and communication in stable and progressive neurological disease. The decrease in mobility in the PND group is likely due to the progressive nature of the disease. The different effect on comfort between groups is mainly due to the smaller effect on startles in the PND group.