Effects of maternal diet and environmental exposure to organochlorine pesticides on newborn weight in Southern Spain. (August 2016)

• Record Type: Journal Article
• Authors: Monteagudo, C.; Mariscal-Arcas, M.; Heras-Gonzalez, L.; Ibañez-Peinado, D.; Rivas, A.; Olea-Serrano, F.
• Is Part Of: Chemosphere. Volume 156(2016)
• Page Start: 135
• Page End: 142
• Publication Date: 2016-08
• Subjects: Organochlorine pesticides -- Umbilical cord blood -- Prenatal exposure -- Mediterranean diet; BMI Body Mass Index -- DDD Dichlorodiphenyldichloroethane -- DDE Dichlorodiphenyldichloroethylene -- DDT Dichlorodiphenyltrichloroethane -- EDCs Endocrine Disrupting Chemicals -- FFQ Food Frequency Questionnaire -- GC/ECD Gas Chromatography and Electron-Capture Detection -- GC/MS Gas Chromatography and Mass Spectrometry -- MD Mediterranean Diet -- MDS-P Mediterranean Dietary Score-Pregnant -- OCPs Organochlorine pesticides -- RDI Reference Dietary Intakes for Spanish population; Pollution -- Periodicals; Pollution -- Physiological effect -- Periodicals; Environmental sciences -- Periodicals; Atmospheric chemistry -- Periodicals; 551.511
• DOI: 10.1016/j.chemosphere.2016.04.103
• Languages: English
• ISSNs: 0045-6535

Abstract

Abstract: An appropriate eating pattern is essential during childbearing years and pregnancy to ensure a healthy pregnancy and newborn. Our group developed a Mediterranean Diet Score for Pregnancy (MDS-P) based on the MD and the specific need of pregnant women for Fe, Ca, and folic acid. Humans are daily exposed to endocrine disruptors, which may alter body weight and hormone system regulation. This study analyzed the relationship of maternal diet and in utero exposure to organochlorine pesticides (OCPs) with newborn weight in mothers and newborns from Southern Spain. Higher MDS-P score, folic acid supplementation, and greater in utero exposure to endosulfan-diol and endosulfan-1 were related to higher newborn weight. MDS-P score was not associated with maternal weight gain during pregnancy (above or below 12 Kg). Residues from one or more OCPs were detected in 96.5% of umbilical cord serum samples from 320 newborns. The most frequent residues were endosulfans (96.5%). The presence of endosulfan-diol, endosulfan-I, p-p´DDT, folic acid supplementation, and a higher MDS-P (>8) were predictive factors for newborn overweight (>3500 g). Conversely, smoking during pregnancy, shorter gestation time (32–36 vs . 37–39 weeks), and lesser maternal weight gain during pregnancy predicted lower newborn weight (<2500 g). These results indicate prenatal exposure to OCPs in Southern Spain and its possible impact on the weight of healthy full-term newborns. Further studies are warranted to interpret the consequences of this exposure and identify preventive measures. Adherence to the MD and folic acid supplementation during pregnancy emerged as predictive factors for overweight in newborns. Highlights: We analyzed prenatal exposure to OCPs and its relationship with newborn weight. We determined OCPs in serum from umbilical cord blood. We measured anthropometric variables in mothers and newborn. OCPs were detected in 95% of umbilical cord serum samples from the 320 newborns. Prenatal exposure to OCPs had an impact on the weight of healthy full-term newborns.